Experiments, visions, and all those steps that brought us to the current state of Cybernetics started with a pion-ear.

Norbert Wiener first created the term "Cybernetics" to evoke the concept of self-regulating mechanisms. Then, in 1998, @Kevin Warwick implants an RFID tag, Stelarc first implanted a "third ear" into his own arm, provoking noise in the art scenario. More notable people came to play the game - Neil Harbisson
Moon Ribas (Cyborg Foundation) Amal Graafstra (Dangerous Things).

Notable mentions go to Ghost in The Shell and Jenova Rain.