Musculoskeletal disorders encompass a range of conditions affecting the muscles, bones, and joints, causing pain and impairing daily functioning. Comparative effectiveness studies have explored the benefits of chiropractic care in managing these disorders, highlighting its effectiveness in reducing pain, improving mobility, and enhancing the overall quality of life. In addition, by integrating chiropractic care into treatment plans, patients can minimize the need for opioid-based treatments and their associated risks.