In terms of chemical structure, they are very similar except testosterone cypionate has an additional carbon atom which makes its half life a bit longer, 8 days while Testosterone Enanthate about 7 days.
Its benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life. The characteristics of testosterone cypionate and testosterone enanthate are very similar, therefore both of them tend to be interchangeable.
Testosterone cypionate shows the same kinetic profile as enanthate. Testosterone propionate must be injected every 2-3 days, but testosterone enanthate (doses of 200-250 mg) and testosterone cypionate have longer durations of action and can be injected every 2-3 weeks, for replacement therapy of hypogonadism.
Both preparations yielded supraphysiological testosterone levels in serum and saliva as early as 2 h following injection, reaching peak levels 4 to 5 times above basal between 8 and 24 h.
Fortunately, it was a straight swap due to the two chemicals being so similiar. So, if you'd would like to switch from Testosterone Enanthate to Cypionate, the same is true, there is no need to adjust your protocol, you can simply switch ester.
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Use of testosterone enanthate has been shown to significantly increase strength within 6-12 weeks of administration (2, 9), however, it is unclear if the ergogenic benefits are evident in less than 6 weeks.
This medication is given by injection into the buttock muscle as directed by your doctor, usually every 1 to 4 weeks. Do not inject this medication into a vein. Dosage is based on your medical condition, testosterone blood levels, and response to treatment.
Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, with no further increments expected beyond. Changes in erections/ejaculations may require up to 6 months. Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer.
Pharmacokinetics. Testosterone enanthate has an elimination half-life of 4.5 days and a mean residence time of 8.5 days when used as a depot intramuscular injection.
Common Testosterone Injection Questions. What's the best time of day to inject testosterone? Traditionally, it's the morning. It's not scientifically necessary to inject testosterone in the morning, though our testosterone is at the highest levels in the morning.
A slower release means fewer testosterone injections per year. Testosterone propionate is a fast-acting ester rarely used in TRT (Testosterone Replacement Therapy). Testosterone enanthate and testosterone cypionate are slow-acting injectable forms.
Levels of circulating testosterone peak within 10 to 12 hours of initial administration, and reach steady state within 24 hours (14).
Testosterone Cypionate (Depo-Tesosterone®) and Testosterone Enanthate (Adrotardyl®) are the two most common forms of testosterone injection esters. Both testosterone cypionate and testosterone enanthate are now available in generic form from many compounding pharmacies with a doctor's prescription.