The usage of cannabinoids in society has a long and complex history, dating back thousands of years. Here is a brief overview of the key milestones:

Ancient Times: Cannabis has been cultivated for its medicinal and psychoactive properties for over 4,000 years. Ancient civilizations in China, India, Egypt, and the Middle East used cannabis preparations for a variety of purposes, including pain relief, relaxation, and spiritual rituals.

19th Century: Cannabis extracts and tinctures were commonly used in Western medicine during this period. Cannabis-based medicines were prescribed for conditions such as pain, insomnia, and nausea.

20th Century: The early 1900s witnessed increased regulation and restriction on cannabis due to social and political factors. The United States implemented the Marihuana Tax Act in 1937, effectively criminalizing the possession and distribution of cannabis.

Late 20th Century: Scientific interest in cannabinoids grew, leading to the discovery of the endocannabinoid system in the 1980s. This system, consisting of cannabinoid receptors and endogenous cannabinoids produced by the body, plays a crucial role in regulating various physiological processes.

21st Century: The 21st century marked a shift in the perception and acceptance of cannabinoids. Medical cannabis programs gained traction in various countries and U.S. states, allowing patients to access cannabinoids for therapeutic purposes. Additionally, the extraction of CBD from hemp gained popularity due to its non-psychoactive nature and potential health benefits.

Present Day: As of 2021, numerous countries and states have legalized medical and/or recreational cannabis, recognizing its potential medicinal value and addressing issues related to criminalization. Research into cannabinoids continues to expand, exploring their therapeutic applications in areas such as pain management, epilepsy, neurodegenerative disorders, and mental health.