Types of Influenza Viruses

Influenzavirus A:

According to different antigenicity of two surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA), influenza A virus can be further divided into 19 HA and 11 NA subtypes. This genus has one species, influenza A virus. Wild aquatic birds are the natural hosts for a large variety of influenza A. The type A viruses are the most virulent human pathogens among the three influenza types and cause the severest disease. The influenza A virus can be subdivided into different serotypes based on the antibody response to these viruses.

Influenzavirus B:

Influenza B viruses cause the same spectrum of disease as influenza A. However, influenza B viruses do not cause pandemics. The only other animals known to be susceptible to influenza B infection are the seal and the ferret. This type of influenza mutates at a rate 2-3 times slower than type A and consequently is less genetically diverse, with only one influenza B serotype. As a result of this lack of antigenic diversity, a degree of immunity to influenza B is usually acquired at an early age. However, influenza B mutates enough that lasting immunity is not possible. This reduced rate of antigenic change, combined with its limited host range (inhibiting cross species antigenic shift), ensures that pandemics of influenza B do not occur.

Influenzavirus C:

Influenza C virus, which infects humans, dogs and pigs, sometimes causing both severe illness and local epidemics. However, influenza C is less common than the other types and usually only causes mild disease in children.

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