The positive effects of nandrolone esters include muscle growth, appetite stimulation and increased red blood cell production, and bone density. Clinical studies have shown them to be effective in treating anemia, osteoporosis, and breast cancer.
Because of its anabolic properties, nandrolone is used among athletes as a doping agent to accelerate muscle growth; to increase lean body mass, strength, and aggressiveness; and to allow faster recovery between athletic performances (4)(5)(6).
The results showed a significant increase of testosterone levels in the culture medium of R2C cells treated with 3.9 µM of nandrolone, while the levels of this hormone did not change at higher doses (15.6 µM) of nandrolone, compared to basal condition.
There is a sharp spike in nandrolone levels 24 to 48 hours after an intramuscular injection of nandrolone decanoate, followed by a steady decline to baseline levels within approximately two or three weeks.
Treatment with nandrolone produced increases of 9.0% and 8.6% in weight and LBM, respectively, in 12 weeks. The increases in weight and LBM with nandrolone use occurred with no statistically significant change in fat mass.
Nandrolone decanoate (Nd) is a highly abused androgenic-anabolic steroid among body builders. Even though it has weak androgenic effects, its prolonged use may have harmful impact on male reproductive system which needs to be evaluated.
How does it enhance an athlete's performance? Nandrolone can improve an athlete's ability to train harder. It reduces tiredness, meaning athletes can recover quicker from a hard training session. It also helps the body to build muscle by producing more protein, which aids the development of muscle tissue.
In April 2017, Pittsburgh Pirates center fielder Starling Marte received an 80-game suspension for a positive test result of nandrolone. In June 2021, Shelby Houlihan, the women's 5k and 1500m American record-holder, received a 4-year ban as the result of a positive test.
No subject experienced toxicity. Conclusion: Nandrolone decanoate has beneficial effects on weight, lean body mass and quality of life in selected patients who have mild to moderate HIV wasting.
The estrogenic activity of nandrolone and stanozolol was further confirmed by their capacity to induce the expression of the ER-regulated gene, CCND1 encoding for the cell cycle regulator cyclin D1, which represents a key protein for the control of breast cancer cell proliferation.
Despite the equivocal findings in rheumatoid arthritis, there are two trials that, while limited, do support a role for nandrolone in the alleviation of non-inflammatory arthralgia.
* nandrolone (deca durabolin/npp) - by itself, deca/npp should not cause much hair loss. If you are taking finasteride (which you should be indefinitely), it will cause significant androgenic hair loss that can last up to 18 months.
Nandrolone decanoate dosing is 100 mg per week for comfort and relief of joint pain and in the dose range of 200 mg to 400 mg per week to increase growth and performance. It is ideally used for about ten to twelve weeks to get the desired results in athletes, powerlifters, and bodybuilders.