When users land on your site, their eye path starts from the upper left corner, and moves on from there.
It means the most important messages should go in the top left corner.

Are you familiar with the Gutenberg diagram? It describes a general pattern the eyes move through when looking at (usually text-heavy) content. It fits this zoning conclusion pretty well, with the exception of the bottom right area.

The left side of the screen always gets more attention because of the F-Shape reading pattern on sites:

Notice also how the top half gets read more. State the most important part of the information right away, use a lot of sub-headlines.

Amazon is a good example of how to take advantage of it: