CRP does not cross the placental barrier and therefore, will be useful in diagnosing infections in newborns. It has been shown that CRP is present in amniotic fluid and fetal urine, and the elevated levels are associated with adverse pregnancy outcome.

CRP and cardiovascular risk

A C-reactive protein test can help doctors determine your risk for heart disease or stroke. CRP is unlikely to contribute directly to cardiovascular disease as a pathogenic factor. Similar conclusions were drawn from recent Mendelian randomization studies. Using widely available high-sensitivity assays, CRP levels of 1, 1 to 3, and 3 mg/L have been classified as low, moderate, and high-risk groups for future cardiovascular events. Individuals with LDL cholesterol below 130 mg/dL and CRP levels of 3 mg/dL represent a high-risk group.