Elevated levels of CRP and IL-6 predict the development of type 2 diabetes. This association supports a possible role for inflammation in diabetogenesis. CRP is a powerful independent predictor of diabetes, after adjustment for obesity, clinical risk factors, and fasting insulin levels. Minor increase in CRP level has also been reported to be associated with a number of medical conditions that do not appear to be associated with inflammation. Elevated CRP is also observed with several genetic polymorphisms of the CRP and other genes, ethnicity, dietary patterns and obesity.

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