Recently, Emma Persson, Kenneth Verstraete and Ines Heyndrickx of the VIB Inflammation Research Center in Belgium found that the key to respiratory tract sinusitis, asthma and other respiratory allergic diseases is the protein crystals in the respiratory tract. The use of antibodies to dissolve these protein crystals can suppress dust allergen-induced airway inflammation. Protein is the cornerstone of the biological body, and various functions in the human body often require different proteins to complete.

These proteins are normally dissolved in body fluids or bound to membrane structures such as cell membranes, and protein crystals are rarely formed. In 1853, Charcot and Robin discovered crystal deposits in the blood and spleen of a leukemia patient; in 1872, Leyden also found the same crystal in the sputum of asthma patients. Therefore, such crystals are also referred to as Charcot-Leyden crystals (CLCs). Studies have shown that the main component in CLCs is Galectin 10 (Gal10). Gal10 is a protein abundant in eosinophils and basophils, and its formation is closely related to the release of extracellular traps of eosinophils.